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Pharmacological Analysis and Molecular Docking of Laurus nobilis (Bay Leaf) for Lung Cancer with Reference to Sirtuin Drug Targets
Seema Rani Padhiary,
Kalpana Priyadarsini Das,
Meeneri Bobde,
Vhatkar Pooja,
Sameer Sharma
Issue:
Volume 9, Issue 2, June 2021
Pages:
11-15
Received:
22 March 2021
Accepted:
8 April 2021
Published:
20 April 2021
Abstract: The aim of this in silico study was to analyze the inhibitory activity of selected phytocompounds from the Bayleaf (Laurus nobilis) in contrast to sirtuin proteins using the various pharmacological tools and molecular docking analysis. Laurus nobilis is a perennial herbs native to the family Lauraceae and it has been cultivated throughout the tropical, European, subtropical, and Asian nations. It has been used for thousands of years for food flavoring, essential oil applications, and in traditional medicine. Mostly, it contains all types of secondary metabolites such as tannins, flavones, flavonoids, alkaloids, eugenol, linalool, methyl chavicol, and anthocyanins. The 3D structures of phytocompounds were retrieved from Pubchem and chemspider databases and subjected to various bioinformatic tools such as SwissADME, Modeller, and Autodock for molecular docking to predict the active binding sites of sirtuin proteins. The comparison of molecular docking score exposed that the targeted phytocompounds showed good binding affinity in contrast to anti-cancer sirtuin proteins. The ADME and Molecular docking properties for drug likeness making them significant agents for biological activities and it is expected to be beneficial and effective for cancer. Bayleaf shows an optimistic results towards the treatment of many diseases. The Bayleaf traditionally has healing properties which has now dragged the attention of science for the betterment of humans. The phytochemical compounds found in and taken in the above research have showed good results with cancer receptors Sirtuin1 and Sirtuin4.
Abstract: The aim of this in silico study was to analyze the inhibitory activity of selected phytocompounds from the Bayleaf (Laurus nobilis) in contrast to sirtuin proteins using the various pharmacological tools and molecular docking analysis. Laurus nobilis is a perennial herbs native to the family Lauraceae and it has been cultivated throughout the tropi...
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Computational Fluid Dynamics Modeling in Respiratory Airways Obstruction: Current Applications and Prospects
Oyejide James Ayodele,
Atoyebi Ebenezer Oluwatosin,
Olutosoye Christian Taiwo,
Ademola Adebukola Dare
Issue:
Volume 9, Issue 2, June 2021
Pages:
16-26
Received:
15 April 2021
Accepted:
3 May 2021
Published:
15 May 2021
Abstract: Breathing conditions pertaining to nasal obstruction, obstructive sleep apnea, and airflow resistance in the human lower airways have been investigated extensively by researchers over the years. Due to the availability of advanced computer numerical models, such as computational fluid dynamics (CFD), researchers have made progressive studies of airflow characteristic, especially the effects of airflow pressure, velocity and wall shear stress in human obstructive airways. Studies utilizing CFD have enhanced clinical understanding of the physiology and pathophysiology of the respiratory system through the concept of three-dimensional models that facilitate airflow simulation. The main objective of this article is to review recent CFD literature on nasal airflow and lower airway obstruction. The review covers the role of segmentation threshold in the outcome of airflow simulation in the nasal cavity, and results of fluid structure interaction (FSI) and computational fluid dynamics in nasal obstruction and airway collapse in obstructive sleep apnea were also correlated. For models of the lower airways, we evaluated the effect of extra-thoracic airway (ETA) on downstream airflow during simulation against the popular Weibel’s model. In the concluding section, we discussed the advantages, limitations, and prospects (precisely with deep machine learning) of computational fluid dynamics in the clinical assessment and investigation of respiratory diseases.
Abstract: Breathing conditions pertaining to nasal obstruction, obstructive sleep apnea, and airflow resistance in the human lower airways have been investigated extensively by researchers over the years. Due to the availability of advanced computer numerical models, such as computational fluid dynamics (CFD), researchers have made progressive studies of air...
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Exploring the Relationship Between Critical Access Hospitals and Rural County Health
Kirtan Patel,
Amber Maraccini,
Timothy Grunert,
Wei Yang,
Anthony Slonim
Issue:
Volume 9, Issue 2, June 2021
Pages:
27-36
Received:
20 May 2021
Accepted:
8 June 2021
Published:
16 June 2021
Abstract: Critical Access Hospitals (CAHs) were developed as a model to improve the access and availability of hospital services in rural counties. There has been limited research on clinical outcomes to evaluate the impact of CAHs since they were authorized through the Balanced Budget Act. This study evaluates CAH’s performance on clinical outcomes, and compares health outcomes between rural counties with CAHs and rural counties without established federally supported hospitals. The American Hospital Association’s (AHA) Annual Survey Database was used to identify CAHs within rural counties and their characteristics. The County Health Rankings (CHR) data were used to quantify health outcomes by county. US rural counties with CAHs versus remaining US rural counties without CAHs were correlated with measures of Clinical Care (p < 0.001). US rural counties with CAHs presented greater health status with regard to All Health Outcomes, p < 0.0001; Length of Life, p < 0.0001; Quality of Life, p < 0.0001; All Health Factors, p < 0.0001; Health Behaviors, p < 0.0001; Social and Economic Environment, p < 0.0001 and Physical Environment, p < 0.0001, than compared to US rural counties without CAHs. Rural counties serviced by CAHs demonstrate better overall health status scores, on several CHR metrics, as compared to rural counties without CAHs. The only exception to this conclusion being that rural counties without CAHs performed superiorly in the CHR metrics related to primary care and mental health services, demonstrating capacities in which CAHs could improve the impact on health in the counties they serve.
Abstract: Critical Access Hospitals (CAHs) were developed as a model to improve the access and availability of hospital services in rural counties. There has been limited research on clinical outcomes to evaluate the impact of CAHs since they were authorized through the Balanced Budget Act. This study evaluates CAH’s performance on clinical outcomes, and com...
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